MTAP supports medical research projects in a wide variety of areas, including cancer, heart disease, stroke, fatty acid transport, neurology, and vascular biology. MTAP will support other areas of medical research as long as the research meets its strategic goals.
Examples of medical research projects supported by MTAP:
AFP-Peptide: A New Drug in the Fight Against Breast Cancer
Albany Medical College
A small molecule peptide, AFPep is effective in the prevention and treatment of breast cancer, including those cancers that have become resistant to tamoxifen, when tested in culture and in animal models. The purpose of this project is to prove that the peptide is effective when delivered orally or by other routes and to determine the safety of the peptide.
Cardioprotective Effects of PQQ in Hypoxic and Ischemia Model Systems
Northern California Institute for Research and Education
This project will test PQQ’s effect in decreasing myocardial injury using an isolated heart model that is subject to ischemia and leads to severe myocardial injury. An in vitro model of cultured adult cardiac mouse myocytes will also be used to study the cardioprotection of PQQ. If PQQ proves to be effective, this will be a useful treatment before cardiac or other surgical procedures, or, possibly, after a heart attack.
Yeast-Based System to Investigate Fatty Acid Transport
Ordway Research Institute, Inc.
The goal of this project is to develop and standardize a live cell high-throughput system useful for identifying inhibitors of fatty acid transport. These inhibitors will limit intestinal absorption of dietary lipid and block fatty acid uptake into cells. This will prevent lipotoxicity, which is linked directly to cardiomyopathy, pancreatitis, and vascular insufficiency. The research holds potential for treatment of various heart, pancreatic, and vascular disorders.
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